Publications

RECENT PUBLICATIONS

Coakley, G., McCaskill, J.L., Borger, J.G., Simbari, F., Robertson, E., Millar, M., Harcus, Y., McSorley, H.J., Maizels, R.M., and Buck, A.H. (2017). Extracellular Vesicles from a Helminth Parasite Suppress Macrophage Activation and Constitute an Effective Vaccine for Protective Immunity. Cell Reports 19, 1545-1557.

McCaskill J, Ressel S, Alber A, Redford J, Power U, Schwarze J, Dutia B, Buck AH (2017) Broad-spectrum inhibition of respiratory virus infection by microRNA mimics targeting p38 MAPK signalling. Mol Therapy Nucleic Acids 7:256-266.

Mateescu, B., Kowal, E.J., van Balkom, B.W., Bartel, S., Bhattacharyya, S.N., Buzas, E.I., Buck, A.H., de Candia, P., Chow, F.W., Das, S., et al. (2017). Obstacles and opportunities in the functional analysis of extracellular vesicle RNA – an ISEV position paper. Journal of Extracellular Vesicles 6, 1286095.

Claycomb J, Abreu-Goodger C, Buck AH (2017) RNA-mediated communication between helminths and their hosts: the missing links. RNA Biology. doi: 10.1080/15476286.2016.1274852.

Quintana JF, Babayan SA, Buck AH (2016). Small RNAs and extracellular vesicles in filarial nematodes: from nematode development to diagnostics. Parasite Immunology doi: 10.1111/pim.12395; PMID: 27748953.

Simbari F, McCaskill J, Coakley G, Millar M, Maizels RM, Fabriás G, Casas J, Buck AH (2016).  Plasmalogen enrichment in exosomes secreted by a nematode parasite versus those derived from its mouse host: implications for exosome stability and biology. Journal of Extracellular Vesicles 5:30741. doi: 10.3402/jev.v5.30741.

Coakley G, Buck AH, Maizels RM (2016). Host parasite communications-Messages from helminthes for the immune system. Mol Biochem Parasitol. 2016 Jul;208(1):33-40. doi: 10.1016/j.molbiopara.2016.06.003.

Tzelos T, Matthews JB, Buck AH, Simbari F, Frew D, Inglis NF, McLean K, Nisbet AJ, Whitelaw CB, Knox DP, McNeilly TN. A preliminary proteomic characterization of extracellular vesicles released by the ovine parasitic nematode, Teladorsagia circumcinta. Vet Parasitology 221:84-92. doi: 10.1016/j.vetpar.2016.03.008.

Coakley G, Maizels RM, Buck AH (2015). Exosomes and other extracellular vesicles: the new communicators in parasite infections. Trends in Parasitology 31(10):477-489.

Nowacki FC, Swain MT, Klychnikov OI, Niazi U, Ivens A, Quintana JF, Hensbergen PJ, Hokke CH, Buck AH and Hoffmann KF (2015). Protein and small non-coding RNA enriched extracellular vesicles are released by the pathogenic bloodfluke Schistosoma mansoni. Journal of Extracellular Vesicles 4:28665, http://dx.doi.org/10.3402/jev.v4.28665.

Buck AH, Ivens A, Gordon K, Craig M, Houzelle A, Roche A, Turnbull N and Beard PM (2015). Quantitative Analysis of MicroRNAs in Vaccinia virus Infection Reveals Diversity in Their Susceptibility to Modification and Suppression.” PLoS One 10(7): e0131787.

Webster CL, Waldron FM, Robertson S, Crowson D, Ferrari G, Quintana JF, Brouqui JM, Bayne EH, Longdon B, Buck AH, Lazzaro BP, Akorli J, Haddrill PR and Obbard DJ (2015). The Discovery, Distribution, and Evolution of Viruses Associated with Drosophila melanogaster.” PLoS Biol 13(7): e1002210.

McCaskill J., Praihirunkit P, Sharp PM and Buck AH (2015). RNA-mediated degradation of microRNAs: A widespread viral strategy?” RNA Biol 12(6): 579-585.

Quintana JF, Makepeace BL, Babayan S, Ivens A, Pfarr KM, Blaxter M, Debrah A, Wanji S, Ngangyung HF, Bah GS, Tanya VT, Taylor DW, Hoerauf A, Buck AH (2015) Extracellular Onchocerca-derived small RNAs in host nodules and blood, Parasites & Vectors 8(1):58.

Kalla R, Ventham NT, Kennedy NA, Quintana JF, Nimmo ER, Buck AH Satsangi J. (2014) MicroRNAs-New players in Inflammatory Bowel Disease Gut, doi:10.1136/gutjnl-2014-307891.

Buck AH, Coakley G, Simbari F, Kumar S, Le Bihan T, Abreu-Goodger C, Lear M, Harcus Y, Ceroni A, Blaxter M, Ivens A, Maizels RM Exosomes secreted by a nematode parasite transfer small RNAs to mammalian cells and regulate genes of the innate immune system Nature Communications DOI:10.1038/ncomm6488.

Hoy A, Lundie R, Ivens A, Quintana J, NauschN, Forster T, Jones F, Kabatereine K,DunneDW, MutapiF, MacDonald AS, Buck AH (2014) Parasite-derived microRNAs in host serum as a novel biomarkers of helminth infection PLOS NTDS DOI:10.1371/journal.pntd.0002701.

Buck, A., & Blaxter, M., Functional diversification of Argonautes in nematodes: an expanding universe” 2013 Biochem Soc Trans 41 (881-886).

Libri, V., Miesen, P., van RIj, RP., Buck, AH. Regulation of microRNA biogenesis and turnover by animals and their viruses (2013) Cell Mol Life Sci, DOI 10.1007/s00018-012-1257-1.

Rückerl, D., Jenkins, S.J., Laqtom, N.N., Gallagher, I.J., Sutherland, T.E., Duncan, S., Buck, A.H.,
and Allen, J. Induction of IL-4Rα-dependent microRNAs identifies PI3K/Akt signaling as essential for IL-4-driven murine macrophage proliferation in vivo. 2012 Blood doi:10.1182/blood-2012-02-408252.

Hoy, A.K., & Buck, A.H. Extracellular small RNAs: what, where, why? Biochem Soc Trans. 2012 40(4): 886-90.

Libri, V., Helwak, A., Miesen, P., Santhakumar, D., Borger, J.G., Kudla, G., Grey, F., Tollervey, D., Buck, A.H., Murine cytomegalovirus encodes a miR-27 inhibitor disguised as a target. 2011 PNAS 10.1073/pnas.1114204109.

Laqtom, N.N., & Buck, A.H., microRNA manipulation as a host-targeted antiviral therapeutic strategy. 2011 European Pharmaceutical Review 16 (6) 52-55.

Santhakumar, D., Forster, T., Laqtom, N., Fragkoudis, F., Dickinson, P., Abreu-Goodger, C., Manakov, SA., Roy Choudhury, N., Griffiths, SJ., Vermeulen, A., Enright, AJ., Dutia, B., Kohl, A., Ghazal, P., Buck, AH. 2010 Combined agonist-antagonist genome-wide functional screening identifies broadly active antiviral microRNAs. PNAS 107, 13830-13835.

Buck, A.H., Perot, J., Chisholm, M.A., Kumar, D.S., Tuddenham, L., Cognat, V., Marcinowski, L., Dolken, L., and Pfeffer, S. 2010 Post-transcriptional regulation of miR-27 in murine cytomegalovirus infection. RNA 16(2): 307-315.

Obbard, D.J., Gordon, K.H., Buck, A.H., and Jiggins, F.M. 2009 The evolution of RNAi as a defence against viruses and transposable elements“. Philos Trans R Soc Lond B Biol Sci 364(1513): 99-115.

Buck, A.H., Santoyo-Lopez, J., Robertson, K.A., Kumar, D.S., Reczko, M., and Ghazal, P. 2007. Discrete clusters of virus-encoded micrornas are associated with complementary strands of the genome and the 7.2-kilobase stable intron in murine cytomegalovirus”. J Virology 81(24): 13761-13770.