Franklin Wang-Ngai Chow

Franklin Wang-Ngai ChowFranklin Wang-Ngai Chow

Location:
Room 3.54

Ashworth 3, Ashworth Laboratories

Telephone: +44 (0)131 651 7807

Email: fchow@ed.ac.uk

 

Academic Background

2015 – Present Postdoctoral Research Associate, IIIR, University of Edinburgh

2013 – 2015 Senior Research Assistant, Department of Microbiology, University of Hong Kong

2010 – 2013 PhD Thesis: “Identification of microRNA in Penicillium marneffei” Supervisors: Prof. Susanna KP Lau and Prof. KY Yuen. Department of Microbiology, University of Hong Kong.

2005 – 2007 MPhil Thesis: ”A study on the in vivo and in vitro embryotrophic effect of complement-3 (C3) ” Supervisor: Prof. William SB Yeung. Department of Obstetrics and Gynaecology, University of Hong Kong.

2002 – 2005 BSc in Biochemistry, University of Hong Kong.

Research Interests

I am interested in molecular microbiology and the small RNA of pathogens, especially the secreted small RNAs and their scope for mediating communication with host cells. My main research focus is the extracellular RNA of the nematode parasite Heligmosomoides polygyrus.

Publications

  1. Lau SK, Chow WN, Foo CH, Curreem SO, Lo GC, Teng JL, Chen JH, Ng RH, Wu AK, Cheung IY, Chau SK, Lung DC, Lee RA, Tse CW, Fung KS, Que TL, Woo PC. Elizabethkingia anophelis bacteremia is associated with clinically significant infections and high mortality. Sci Rep. 2016 May 17;6:26045.
  2. Lau SK, Yip CC, Zhao PS, Chow WN, To KK, Wu AK, Yuen KY, Woo PC. Enterovirus D68 Infections Associated with Severe Respiratory Illness in Elderly Patients and Emergence of a Novel Clade in Hong Kong. Sci Rep. 2016 Apr 28;6:25147.
  3. Lau SKP, Chow WN (co-first author), Wong AYP, Yeung JMY, Bao J, Zhang N, Lok S, Woo PC, Yuen KY. (2013) Identification of microRNA-like RNAs in mycelial and yeast phases of the thermal dimorphic fungus Penicillium marneffei. PLOS Neglected Tropical Diseases. 2013 Aug 22;7(8):e2398.
  4. Lau SKP, Lam CW, Curreem SOT, Lee KC, Chow WN, Lau CCY, Sridhar S, Wong SCY, Martelli P, Hui SW, Yuen KY, Woo PCY. Metabolomic profiling of Burkholderia pseudomallei using UHPLC-ESI-Q-TOF-MS reveals specific biomarkers including 4-methyl-5-thiazoleethanol and unique thiamine degradation pathway. Cell & Bioscience. 2015 Jun 2;5:26.
  5. Lau SKP, Sridhar S, Ho CC, Chow WN, Lee KC, Lam CW, Yuen KY, Woo PC. Laboratory diagnosis of melioidosis: Past, present and future. Exp Biol Med (Maywood). 2015 Jun;240(6):742-51.
  6. Lau SKP, Lam CW, Curreem SOT, Lee KC, Lau CCY, Chow WN, Ngan AHY, To KKW, Chan JFW, Hung IFN, Yam WC, Yuen KY, Woo PCY. Identification of specific metabolites in culture supernatant of Mycobacterium tuberculosis using metabolomics approach: an exploration of potential biomarkers for diagnosis. Emerging Microbes & Infections (2015) 4, e6
  7. Yang E, Chow WN, Wang G, Woo, PCY, Lau SKP, Yuen KY, Lin X, Cai JJ. Signature gene expression reveals novel clues on the mechanism of dimorphic transition in Penicillium marneffei. PLOS Genetics. 2014 Oct 16;10(10):e1004662.
  8. Yang E, Wang G, Woo PC, Lau SKP, Chong KTK, Tse H, Kao RYT, Chan CM, Chow WN, Yuen KY, Cai JJ. Unraveling the molecular basis of temperature-dependent genetic regulation in Penicillium marneffei. Eukaryotic Cell. 2013 Sep;12(9):1214-24.
  9. Woo PC, Lau SKP, Liu B, Cai JJ, Chong KT, Tse H, Kao RY, Chan CM, Chow WN, Yuen KY. Draft genome sequence of Penicillium marneffei strain PM1. Eukaryotic Cell. 2011 Dec;10(12):1740-1.
  10. Chow WN, Lee YL, Wong PC, Chung MK, Lee KF, Yeung WSB. Complement 3 deficiency impairs early pregnancy in mice. Molecular Reproduction and Development. 2009 Jul;76, 647-55.
  11. Tse PK, Lee YL, Chow WN, Luk JMC, Lee KF, Yeung WSB. Preimplantation embryos co-operates with oviductal cells to produce embryotrophic iC3b. Endocrinology, 2008 Mar ;149(3):1268-76.
  12. Lee YL, Chan YL, Chow WN, Ng EH, Lee KF, Yeung WSB, Ho PC. EG-VEGF stimulates proliferation and tube formation in human uterine microvascular endothelial cell through the MAPK but not the Akt pathway. Fertility and Sterility. 2009 May;91(5 Suppl):2163-71.
  13. Lee YL, Cheong AWY, Chow WN, Lee KF, Yeung WSB. Regulation of Complement 3 expression in human and mouse oviducts. Molecular Reproduction and Development, 2009 Mar;76(3):301-8.

Biosketch

Franklin Wang-Ngai Chow was awarded a Bachelor of Science from the University of Hong Kong for his work on studying the regulation of the embryotrophic factor Complement-3 (C3) expression in mouse and human oviduct. He continued this study to investigate the effect of deficiency of C3 in mice fertility and fecundity during his MPhil research. He was then moved to the microbiology field and developed the interests on molecular microbiology and small RNA biology. Dr. Chow subsequently conducted his PhD research at the Department of Microbiology in the University of Hong Kong. The primary focus of his PhD thesis was the dicer dependent microRNA-like RNAs in the thermal dimorphic pathogenic fungi Penicillium marenffei and the RNAi proteins in relations to virulence in this fungal pathogen.

Dr. Chow joined the Buck lab in 2015 to investigate extracellular RNA in the nematode parasite Heligmosomoides polygyrus is part of a Human Frontiers in Science team to probe RNA-mediated cross species communication using this model.